The theme’s ground is based on our expertise in designing and studying molecular hybrid structures and their optoelectronic and supramolecular behaviors in gas, liquid, and solid phases (ACIE 2014, CEJ 2016, CEJ 2018, ACIE 2019, CEJ 2020, EJOC 2020, Chem. Sci. 2020, JACS 2022, Chem. Comm. 2023). Moreover, our present self-image encompasses the synthesis of promising (molecular) materials with a focus on sustainability and efficiency, a commitment we've substantiated across various functional molecular scaffolds (ACIE 2016, Nature Comm. 2018, CEJ 2020, Chem. Methods 2021, CAJ 2023). Our first demonstration of a hybrid nanomachine demonstrates the versatility and operational complexity, once concepts from supramolecular chemistry are interwoven with inorganic materials and organic macromolecules (Nature Nanotech. 2024).
The theme explores in an interdisciplinary manner, precise molecular properties in synergy with (in)organic nanomaterials to manipulate processes at the nanoscale, to be applied for instance at biological interfaces. Hereby, we will use the concept of molecular machines into hierarchically assembled nanomachines controlled with quantum chemical precision. We will extend the realm of organic chemistry beyond the confines of individual molecules and incorporate functional molecules into polymeric networks and inorganic interfaces with a robust chemical rationale.
A particular interest lies in exploring and enhancing the capabilities of biocompatible hydrogels that can respond remotely to precise stimuli, such as light, magnetic waves, or ultrasound. Such modalities make potential (soft) nanomachineries externally controllable for precise mechanical actuations. This endeavor involves the integration of molecular photomuscles, as well as magnetic nanoparticles into the polymeric matrix of these gels. These novel materials will be investigated for their potential in soft robotics, where they can offer unique mechanical properties at the bio interface. To divert from purely externally controlled machineries, we will equip the architectures with sensory systems, which will control the mechanical output by monitoring and responding to microenvironmental changes in real-time.
To achieve this, we are developing strategies that enable us to synthesize functional core-shell hydrogel scaffolds, which empowers us to introduce a diverse range of functionalities while also manipulating the viscoelastic properties of these materials. These dynamic soft materials will possess distinct optoelectronic, bioresponsive, and mechanical attributes that are intricately linked and controlled through the molecular designs we apply.
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